Location

Rua Câmara Pestana nº 6, room 2.23 1150-082 Lisboa, PORTUGAL
Phone: 218803100 Ext: 26047

Michel Kranendonk

Investigador  Investigador Principal
2019 Member of the International Advisory Committee of the Cytochrome P450 Conferences (https://my.vanderbilt.edu/p450meetings/iac/) 2018 Member of the Management Committee of the EU COST Action Prospective European Drug Induced Liver Injury Network 2015 Leader of the research group Xenobiotic Metabolism of the Center for Toxicogenomics and Health (ToxOmics), UNL
Esteves F, Rueff J, Kranendonk M. The Central Role of Cytochrome P450 in Xenobiotic Metabolism-A Brief Review on a Fascinating Enzyme Family. Journal of Xenobiotics (2021) 11, 94-114. DOI: 10.3390/jox11030007 Fernandez-Checa JC, Bagnaninchi P, Ye H, Sancho-Bru P, Falcon-Perez JM, Royo F, Garcia-Ruiz C, Konu O, Miranda J, Lunov O, Dejneka A, Elfick A, McDonald A, Sullivan GJ, Aithal GP, Lucena MI, Andrade RJ, Fromenty B, Kranendonk M, Cubero FJ, Nelson LJ. Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]. Journal of Hepatology (2021), 24, S0168-8278(21)00441-4 DOI: 10.1016/j.jhep.2021.06.021 Esteves F, Urban P, Rueff J, Truan G, Kranendonk M. Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding. International Journal Molecular Science (2020) 21(18): 6669 DOI: 10.3390/ijms21186669 Esteves F, Campelo D, Gomes BC, Urban P, Bozonnet S, Lautier T, Rueff J, Truan G, Kranendonk M. The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions with Structurally Diverse Redox Partners. Frontiers in Pharmacology (2020) 11:299. eCollection 2020. DOI: 10.3389/fphar.2020.00299 Campelo D, Esteves F, Brito Palma B, Costa Gomes B, Rueff J, Lautier T, Urban P, Truan G, Kranendonk M. Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450. International Journal of Molecular Sciences, (2018) 19: pii: E3914. DOI: 10.3390/ijms19123914 Amit Pandey, Colin James Henderson, Yuji Ishii, Michel Kranendonk, Wayne Backes and Ulrich Zanger Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function Frontiers in Pharmacology (2017), 8:881 DOI: 10.3389/fphar.2017.00881 Diana Campelo, Thomas Lautier, Philippe Urban, Francisco Esteves, Sophie Bozonnet, Gilles Truan and Michel Kranendonk. The hinge segment of human NADPH-cytochrome P450 reductase in conformational switching: the critical role of ionic strength. Frontiers in Pharmacology (2017) 8:755 DOI: 10.3389/fphar.2017.00755 McCammon KM, Panda SP, Xia C, Kim JJ, Moutinho D, Kranendonk M, Auchus RJ, Lafer EM, Ghosh D, Martasek P, Kar R, Masters BS, Roman LJ. Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype. Journal of Biological Chemistry (2016), 291:20487-502. DOI: 10.1074/jbc.M116.716019
ORCID: 0000-0003-1362-0076; PURE: https://novaresearch.unl.pt/en/persons/michel-kranendonk website laboratory: http://cigmh.fcm.unl.pt/xenobiotic-metabolism/