Controlo Neuronal das Doenças Metabólicas: Estratégias Terapêuticas

Os distúrbios metabólicos como a obesidade e diabetes tipo 2 (DM2) afetam milhões de indivíduos em todo o mundo, contribuindo para uma significativa morbidade e mortalidade. As estratégias terapêuticas para estas patologias são escassas. O nosso grupo de investigação está focado em explorar os mecanismos fisiopatológicos por detrás do desenvolvimento das doenças metabólicas e na identificação de estratégias para prevenir e tratar estas patologias.

A nossa abordagem científica é translacional e multidisciplinar, e engloba investigação cientifica que vai desde o estudo em modelos celulares, até modelos animais e investigação no Homem. Para atingirmos os nossos objetivos usamos vários tipos de metodologias que vão desde a bioquímica, a biologia celular, imagiologia, eletrofisiologia e estudos in vivo, estando também focados no desenvolvimento de ferramentas matemáticas e computacionais para análise de dados na tentativa de promover o bem-estar dos doentes com doenças metabólicas.

Our research areas:

1- Role of autonomic nervous system and in particular the carotid body (CB), a peripheral chemoreceptor, on the genesis of metabolic disorders

Esquema1

Ribeiro et al. 2013. Diabetes; Sacramento et al. 2017. Diabetologia; Conde et al. 2017 J Physiol; Ribeiro et al. 2018. J Physiol; Conde et al. 2018. Physiol Genomics; Sacramento et al. 2020. IJMS; Cunha-Guimaraes et al. 2020 EJE

 

2- Modulation of adenosine and/or dopamine signaling/metabolism in insulin-sensitive tissues to ameliorate glucose metabolism and tissue function in metabolic diseases.

esquema 2

Conde et al. 2012. BJN; Guarino et al 2013 Age; Sacramento et al. 2015. EJPS; Sacramento et al. 2020 Front Endoc

 

3- Exploring molecular players and pathways to promote adipose tissue browning as targets for obesity and type 2 diabetes

esquema3

4- Modulation of peripheral nerves to treat metabolic diseases, e.g. by the use of bioelectroceuticals

esquema4

Sacramento et al. 2018 Diabetologia; Cracchiolo et al. 2019 IEEE  

 

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Jan 2022 - Jun 2023 – “Moving towards closed-loop bioelectronic medicine for type 2 diabetes: real-time neuromodulation of carotid sinus nerve” Supported by Portuguese Foundation for Science and Technology.  Project Reference: EXPL/MED-NEU/0733/2021. PI: Joana Sacramento

2021-2022: “In the crossroad between metabolic and neurodegenerative diseases” Financiado por: iNOVA4Health - 6,000€ (financiamento para  2021). PI: Silvia V. Conde e Hugo Vicente Miranda.

Aug 2016 - June 2019 - “The Carotid Body as a therapeutic target in metabolic diseases: Mapping carotid sinus nerve activity in diabetes rat models: Lisbon Stage 2”. supported by: Galvani Bioelectronics - 340.316,00€ - PI: Sílvia Conde

Nov 2013 - Apr 2016 - “The Carotid Body as a therapeutic target in metabolic diseases: Mapping carotid sinus nerve activity in diabetes rat models”. supported by: GSK Bioelectronic Exploratory Funding - 147.905,56€ PI: Sílvia Conde

Mar 2015 - Apr 2016 - "Wireless Interfacing of the Carotid Sinus Nerve for Hypoxic Response Modulation". Collaboration project between CEDOC, NOVA Medical School, University of Texas and Illinois Institute of Technology. Supported by: GSK Innovation Challenge Funding. 200.000$ (total), 49.728$ (Silvia Conde). co-PIs: Mário Romero and Sílvia Conde

Mar 2014 - Feb 2015 – “Mapping the sympathetic efferent activity in carotid-body mediated insulin resistance”. Supported by: Portuguese Foundation for Science and Technology (EXPL/NEU-SCC/2183/2013) – 48.371€ PI: Maria Guarino

Nov 2013 - Nov 2014 - "Mapping carotid sinus nerve activity in diabetes rat models" Supported by: GSK Bioelectronic Exploratory Funding Ref: D00006317 - 96.105$ PI: Silvia Conde

Mar 2011 - Dec 2013 - "Insulin and carotid body: a new mechanism for insulin resistance and hypertension.".Supported by Portuguese Foundation for Science and Technology Project Reference: PTDC/SAU-ORG/11149/2009 - 100.000€ PI: Silvia Conde

Nov 2009 - May 2012: Effect of chronic caffeine intake on insulin resistance and hypertension: mechanistic and therapeutic approach. Supported by: Sociedade Portuguesa Diabetologia/Lilly Portugal - 10.000 € PI: Silvia Conde and Maria Guarino

2021 Prémio de Investigação Alfredo da Silva: “CB meter – um novo dispositivo para a deteção o precoce da diabetes mellitus tipo 2”, Fundação Amélia de Mello, Portugal.

2021 Award Pedro Eurico Lisboa to the best paper in the Diabetes field: Carotid body chemosensitivity: early biomarker of dysmetabolism in humans. Joao P Cunha-Guimaraes et al. 2020 Eur J Endocrin 182: 549-557.

2021 Best Oral Communication in the field of Fundamental Research in the 17th Portuguese Congress of Diabetes. 

2020 Best poster communication in the category of nutrition by the Portuguese Society for the study of Obesity (SPEO) in the 24th Portuguese Obesity Congress. 

2020 Honor award for the poster communication in the category of Obesity and its Comorbidities by the Portuguese Society for the study of Obesity (SPEO) in the 24th Portuguese Obesity Congress. 

2019 Eurico Lisboa Honor Award from the Portuguese Society of Diabetes- Best publication in the Diabetes: Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes. Sacramento et al. 2018 Diabetologia 61:700-710.

2018 Pulido Valente/FCT Award – Best publication in Biomedical Engineering “Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes.” Sacramento et al. 2018 Diabetologia 61:700-710

2017 Eurico Lisboa Award from the Portuguese Society of Diabetes- Best publication in the Diabetes field “Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver. Sacramento et al. 2017 Diabetologia. 60:158-168

2017 1st Prize “De Castro-Heymans- Neil Award” by ISAC (International Society for Arterial Chemoreception) to the best work presented by a Young Research each triennial ISAC Meeting. (to Joana F. Sacramento)

2016 National Diabetes Award 2016 from the Portuguese Society of Diabetes

2016 Hargreaves 2016 Award from the Portuguese Society of Diabetes/JABA RECORDATI

2014 Best project in the Translational Research category by Fundação AstraZeneca Innovate Competition. (to Bernardete Melo)


2014 1st Prize “De Castro-Heymans- Neil Award” by ISAC (International Society for Arterial Chemoreception) to the best work presented by a Young Research each triennial ISAC Meeting. ( to Maria João Ribeiro)


2014 EPHAR Young Investigator Award from the Federation of European Pharmacological Societies to best scientific article published in the area of pharmacology. (to Maria João Ribeiro)


2012 Hargreaves 2012 Award from the Portuguese Society of Diabetes /JABA RECORDATI
2009 L’Oreal Portugal Medals of Honour for Women in Science from L’Oreal, Portuguese Science and Technology Foundation and UNESCO (to Silvia conde)


2009 Nuno Castel Branco Award from the Portuguese Society of Diabetes and Lilly Portugal (to Silvia Conde and Maria Guarino)

  • Conde SV, Chew DJ, Famm K, Guarino MP, Holinski B, Patel S (2015) Neuromodulation device. Patent PCT/PT2015/000047. International Bureau WO/2016/072875. Licensed to Galvani Bioelectronics in May 2016. 
  • Micera S, Panarese A, Mazzoni A, Carpanato J, Cracchiolo M, Ramnarain N, Conde SV (2017) A SYSTEM FOR MONITORING AND TREATING METABOLIC DISORDERS. Patent No. 102017000148492
Bolsa de Investigação (BI) para o desenvolvimento de atividades de I&D a realizar por estudante de Doutoramento ou por Licenciado ou Mestre inscrito em curso não conferente de grau @ Sílvia Conde Lab (SAI/2022/06)
Bolsas

Encontra-se aberto concurso para a atribuição de uma Bolsa de Investigação (BI) para o desenvolvimento de atividades de I&D a realizar por estudante de Doutoramento ou por Licenciado ou Mestre inscrito em curso não conferente de grau, com a referência SAI/2022/06, no âmbito do projeto EXPL/MED-NEU/0733/2021, na instituição Faculdade de Ciências Médicas|NOVA Medical School (FCM|FCM) da Universidade NOVA de Lisboa (UNL), suportado por receitas provenientes do projeto acima referido, financiado pela Fundação para a Ciência e a Tecnologia, I.P. (FCT, I.P.).

Data limite de candidatura: 27 de maio 2022 (até às 17h00).

Plasticidade do tecido adiposo explicado a jovens por investigadoras NMS

As investigadoras do grupo Controlo Neuronal das Doenças Metabólicas publicaram na Frontiers for Young Minds uma revisão do conhecimento existente sobre a forma como as nossas células que acumulam gordura evoluem ao longo do tempo. 

NMS Research com forte representação em congresso internacional de diabetes

Os grupos das investigadoras Paula Macedo e Sílvia Conde fizeram várias apresentações no congresso europeu EASD 2022, que ocorreu em Estocolmo.

  • Maria Guarino e Rui-Fonseca Pinto, CiTechCare, Instituto Politecnico de Leiria, Leiria, Portugal
  • Paulo Matafome eRaquel Seiça – iCBR , Coimbra Institute for Clinical and Biomedical Research, Coimbra, Portugal
  • Helena Vieira – Cell Death and Disease group, Faculdade Ciências e Tecnologia
  • Phillipe Blancou and Nicolas Glaichenhaus: Institut de Pharmacologie Moléculaire et Cellulaire, Université Côte d'Azur, Nice, França - 
  • Phill Miliken, Galvani Bioelectronics - GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, UK- 
  • Silvestro Micera:  Sant'Anna School of Advanced Studies, Pisa, Itália 
  • Mario Romero: Department of Biomedical Engineering, University of Houston, Houston, TX, USA
  • Ana Obeso, Asuncion Rocher, Elena Olea, Jesus Prieto-Lloret - Faculty of Medicine, University of Valladolid, Spain

Investigador Principal

Sílvia Vilares Conde
Principal Investigator

Equipa

Miguel Cardoso
Research Associate
Fátima Patrícia Oliveira Martins
Junior Researcher FCT Scientific Employment Stimulus
Joana F. Sacramento
Junior Researcher FCT Scientific Employment Stimulus
Bernardete Melo
PhD student
Adriana Capucho
Master Student
Joana Fernandes
Master Student
Dinis Pires
Master Student