Rua Câmara Pestana nº 6, 6A e 6B 1150-082 Lisboa, Portugal
Telefone: 351218803108

Maria Paula Macedo

Docente Professor Catedrático
Principal Investigator (PI)
  • Professor & Member Pedagogic Council NMS
  • Steering Com. NAFLD-EASD
  • Council Euro. Soc. Clinical Invest.
  • Direction APDP-Diabetes
  • Direction Soc. Portuguesa Diabetologia
  • Vice-President Fund. Ernesto Roma

Most relevant papers from last 3 years:

• Rita S. Patarrão; ...; M. Paula Macedo #; Carlos Penha-Gonçalves#, Prediabetes Blunts CD26/DPP4 Genetic Control of Postprandial Glycemia and Insulin Secretion. Diabetologia in print

• Coelho I, ..., Macedo MP, Penha-Gonçalves Insights into Macrophage/Monocyte-Endothelial Cell Crosstalk in the Liver: A Role for Trem-2. J Clin Med. 2021;10(6):1248. • Ferreira I,..., Macedo MP, Messages From the Small Intestine Carried by Extracellular Vesicles in Prediabetes: a Proteomic Portrait. Journal of Proteome Research in press and BioRxiv 2021 DOI: 10.1101/2021.02.19.431856

• Sousa L, …, Macedo MP#, Vicente Miranda H.J# Insulin-degrading enzyme: an ally against metabolic and neurodegenerative diseases. J Pathol. 2021 • Borges DO,..., Macedo MP. Loss of postprandial insulin clearance control by Insulin-Degrading Enzyme drives dysmetabolism traits. Metabolism Clinical and Experimental. 2021;118:154735. • Coelho I, ..., Macedo MP , Penha-Goncalves C. Trem-2 Promotes Emergence of Restorative Macrophages and Endothelial Cells During Recovery From Hepatic Tissue Damage. Front Immunol.2021,8;11:616044.

• Pinheiro T,..., Macedo MP, Águas H, Martins R, Fortunato E. Paper-Based In-Situ Gold Nanoparticle Synthesis for Colorimetric, Non-Enzymatic Glucose Level Determination. Nanomaterials (Basel). 2020 14;10(10). • Svegliati-Baroni G, …, Macedo MP#, Gastaldelli A. # Gut-Pancreas-Liver Axis as a Target for Treatment of NAFLD/NASH. Int J Mol Sci. 2020; 21(16):5820. • Pina AF,.., Macedo MP. Insulin: Trigger and Target of Renal Functions. Front Cell Dev Biol. 2020 29;8:519.

• Sousa-Lima I,..., Macedo MP. S-Nitrosoglutathione Reverts Dietary Sucrose-Induced Insulin Resistance. Antioxidants 2020, 9(9):870. • Pina AF, ..., Macedo MP. Metabolic Footprint, towards Understanding Type 2 Diabetes beyond Glycemia. Journal of Clinical Medicine 2020, 9(8):2588.

• Bergman M, …, Macedo MP, Ribeiro RT, Raposo JF, Dorcely B, Ibrahim N, Buysschaert M. Review of methods for detecting glycemic disorders. Diabetes Research and Clinical Practice 2020, 165:108233.

• Bento G,..., Macedo MP, Oliveira PJ. Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine. Cells 2020, 9:573. • Pina A, …, Macedo MP, Valenti L, Volpe G, Romeo S. Virtual genetic diagnosis for familial hypercholesterolemia powered by machine learning. European Journal of Preventive Cardiology 2020.

• Silva J, ..., Macedo MP#, Jones JG#. Contributions of Exogenous Glucose and Fructose to de novo Fatty Acid and Glycerol Synthesis in Liver and Adipose Tissue. Metabolic Engineering 2019, 2019 Dec;56:69.

• Meneses MJ, ..., Macedo MP. Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis: Impact on the Onset and Progression of Metabolic Disorders. International Journal of Molecular Sciences. 2019 Aug 20(16):4049.

• Belew GD, ..., Macedo MP, Jones JG. Transfer of glucose hydrogens via acetyl-CoA, to fatty acids during de novo lipogenesis. Journal of Lipid Research. 2019 Dec;60(12):2050.

• Meneses MJ,..., Macedo MP#, Alves MG#. Insulin-degrading enzyme leads to mice testicular morphological changes and impaired sperm quality. Mol Cell Endocrinol. 2019 15;486:11.

• Matos AM, ..., Macedo MP, Contino M, Colabufo N, Rauter AP. Design and synthesis of CNS-targeted flavones and analogues against H2O2- and Abeta1-42-induced toxicity. Pharmaceutics. 2019; 12(2): 98

• Dias C, …, Macedo MP, Colabufo N, Rauter AP, 2-Deoxyglycosylation towards more effective and bioavailable neuroprotective molecules inspired by nature. Pure and Applied Chemistry.2019, 7;91:1209

• Huang H, Lee S, Sousa-Lima I, … Park KS, Macedo MP, White M, Jones J, Kim YB. Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition. J Clin Invest. 2018,3;128(12):5335-5350.

• Duarte N, ..., Macedo MP. Dipeptidyl Peptidase-4 is a Pro-recovery Mediator During Acute Hepatotoxic Damage and Mirrors Severe Shifts in Kupffer Cells. Hepatology Com. 2018,7;2(9):1080

  • Charneco da Costa - SPD/Sanofi ( 2020)
  • Nuno Castelo Branco SPD/Lilly Portugal (2020)
  • Pedro Eurico Lisboa - SPD / Lilly (2019)
  • Prémio Nacional de Diabetologia (2019)
  • Prize Group of Fundamental and Translational Research (GIFT) - Portuguese Diabetes Society (2019)
  • Nuno Castelo Branco SPD/Lilly Portugal (2018)
  • Prize Group of Fundamental and Translational Research (GIFT) - Portuguese Diabetes Society (2018)
  • Pedro Eurico Lisboa SPD/Bayer (2014)
  • Hargreaves Prize SPD/JABA - Soc. Portuguesa de Diabetologia (2011)
  • Nuno Castel-Branco SPD/Lilly Portugal (2011)
  • Pedro Eurico Lisboa SPD/Bayer (2011)
  • Prize Ernesto Roma - Associação Protetora Diabéticos de Portugal (2011)
  • Hargreaves Prize SPD/JABA - Soc. Portuguesa de DiabetologiaAward (2008)
  • Sá Marques/SPD - Sociedade Portuguesa de DiabetologiaAward (2008)
  • Best Scientific Presentation - Western Pharmacology SocietyAward (2007)
  • Peter E. Dresel Award for the best oral presentation at the joint meeting of British Pharmacol. Soc. - BPS and SPC