Metabolic disorders like obesity and type 2 diabetes (T2D) affect millions of individuals, contributing to significant morbidity and mortality worldwide. The therapeutic strategies are scarce. Our group is focused on exploring the pathophysiological mechanisms behind the development of metabolic diseases and in the identification of prevention strategies and treatment interventions that would help stem this epidemic.
We have a translational and multidisciplinary scientific approach, going from the study in cells, to animals and humans. As such, we use traditional and cutting edge methodologies going from biochemistry, to cell and tissue biology and imaging, to electrophysiology and in vivo studies. We are also focused on the development of mathematical and computational tools to analyze data and to promote the wellbeing of metabolic disease patients.
Our research areas:
1- Role of autonomic nervous system and in particular the carotid body (CB), a peripheral chemoreceptor, on the genesis of metabolic disorders
Ribeiro et al. 2013. Diabetes; Sacramento et al. 2017. Diabetologia; Conde et al. 2017 J Physiol; Ribeiro et al. 2018. J Physiol; Conde et al. 2018. Physiol Genomics; Sacramento et al. 2020. IJMS; Cunha-Guimaraes et al. 2020 EJE
2- Modulation of adenosine and/or dopamine signaling/metabolism in insulin-sensitive tissues to ameliorate glucose metabolism and tissue function in metabolic diseases.
Conde et al. 2012. BJN; Guarino et al 2013 Age; Sacramento et al. 2015. EJPS; Sacramento et al. 2020 Front Endoc
3- Exploring molecular players and pathways to promote adipose tissue browning as targets for obesity and type 2 diabetes
4- Modulation of peripheral nerves to treat metabolic diseases, e.g. by the use of bioelectroceuticals
Sacramento et al. 2018 Diabetologia; Cracchiolo et al. 2019 IEEE
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Jan 2022 – Jun 2023 "Moving towards closed-loop bioelectronic medicine for type 2 diabetes: real-time neuromodulation of carotid sinus nerve". EXPL/MED-NEU/0733/2021. Supported by: Fundação para a Ciência e Tecnologia. - 49.986,92 € PI: Joana Sacramento
2021-2022: “In the crossroad between metabolic and neurodegenerative diseases” Supported by iNOVA4Health - 6,000€ (financial support for 2021). PI: Silvia V. Conde and Hugo Vicente Miranda.
Aug 2016 - Feb 2018 - “The Carotid Body as a therapeutic target in metabolic diseases: Mapping carotid sinus nerve activity in diabetes rat models: Lisbon Stage 2”. supported by: Galvani Bioelectronics - 340.316,00€ - PI: Sílvia Conde
Nov 2013 - Apr 2016 - “The Carotid Body as a therapeutic target in metabolic diseases: Mapping carotid sinus nerve activity in diabetes rat models”. supported by: GSK Bioelectronic Exploratory Funding - 147.905,56€ PI: Sílvia Conde
Mar 2015 - Apr 2016 - "Wireless Interfacing of the Carotid Sinus Nerve for Hypoxic Response Modulation". Collaboration project between CEDOC, NOVA Medical School, University of Texas and Illinois Institute of Technology. Supported by: GSK Innovation Challenge Funding. 200.000$ (total), 49.728$ (Silvia Conde). co-PIs: Mário Romero and Sílvia Conde
Mar 2014 - Feb 2015 – “Mapping the sympathetic efferent activity in carotid-body mediated insulin resistance”. Supported by: Portuguese Foundation for Science and Technology (EXPL/NEU-SCC/2183/2013) – 48.371€ PI: Maria Guarino
Nov 2013 - Nov 2014 - "Mapping carotid sinus nerve activity in diabetes rat models" Supported by: GSK Bioelectronic Exploratory Funding Ref: D00006317 - 96.105$ PI: Silvia Conde
Mar 2011 - Dec 2013 - "Insulin and carotid body: a new mechanism for insulin resistance and hypertension.".Supported by Portuguese Foundation for Science and Technology Project Reference: PTDC/SAU-ORG/11149/2009 - 100.000€ PI: Silvia Conde
Nov 2009 - May 2012: Effect of chronic caffeine intake on insulin resistance and hypertension: mechanistic and therapeutic approach. Supported by: Sociedade Portuguesa Diabetologia/Lilly Portugal - 10.000 € PI: Silvia Conde and Maria Guarino
- Peripheral Dopamine Directly Acts on Insulin-Sensitive Tissues to Regulate Insulin Signaling and Metabolic Function
- Dopamine D2 receptor agonist, bromocriptine, remodels adipose tissue dopaminergic signalling and upregulates catabolic pathways, improving metabolic profile in type 2 diabetes
- Chronic Intermittent Hypoxia Induces Early-Stage Metabolic Dysfunction Independently of Adipose Tissue Deregulation
- Carotid body chemosensitivity: early biomarker of dysmetabolism in humans
- Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes
2021 Prémio de Investigação Alfredo da Silva: “CB meter – um novo dispositivo para a deteção o precoce da diabetes mellitus tipo 2”, Fundação Amélia de Mello, Portugal.
2021 Award Pedro Eurico Lisboa to the best paper in the Diabetes field: Carotid body chemosensitivity: early biomarker of dysmetabolism in humans. Joao P Cunha-Guimaraes et al. 2020 Eur J Endocrin 182: 549-557.
2021 Best Oral Communication in the field of Fundamental Research in the 17th Portuguese Congress of Diabetes.
2020 Best poster communication in the category of nutrition by the Portuguese Society for the study of Obesity (SPEO) in the 24th Portuguese Obesity Congress.
2020 Honor award for the poster communication in the category of Obesity and its Comorbidities by the Portuguese Society for the study of Obesity (SPEO) in the 24th Portuguese Obesity Congress.
2019 Eurico Lisboa Honor Award from the Portuguese Society of Diabetes- Best publication in the Diabetes: Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes. Sacramento et al. 2018 Diabetologia 61:700-710.
2018 Pulido Valente/FCT Award – Best publication in Biomedical Engineering “Bioelectronic modulation of carotid sinus nerve activity in the rat: a potential therapeutic approach for type 2 diabetes.” Sacramento et al. 2018 Diabetologia 61:700-710
2017 Eurico Lisboa Award from the Portuguese Society of Diabetes- Best publication in the Diabetes field “Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver. Sacramento et al. 2017 Diabetologia. 60:158-168
2017 1st Prize “De Castro-Heymans- Neil Award” by ISAC (International Society for Arterial Chemoreception) to the best work presented by a Young Research each triennial ISAC Meeting. (to Joana F. Sacramento)
2016 National Diabetes Award 2016 from the Portuguese Society of Diabetes
2016 Hargreaves 2016 Award from the Portuguese Society of Diabetes/JABA RECORDATI
2014 Best project in the Translational Research category by Fundação AstraZeneca Innovate Competition. (to Bernardete Melo)2014 1st Prize “De Castro-Heymans- Neil Award” by ISAC (International Society for Arterial Chemoreception) to the best work presented by a Young Research each triennial ISAC Meeting. ( to Maria João Ribeiro)2014 EPHAR Young Investigator Award from the Federation of European Pharmacological Societies to best scientific article published in the area of pharmacology. (to Maria João Ribeiro)2012 Hargreaves 2012 Award from the Portuguese Society of Diabetes /JABA RECORDATI2009 L’Oreal Portugal Medals of Honour for Women in Science from L’Oreal, Portuguese Science and Technology Foundation and UNESCO (to Silvia conde)2009 Nuno Castel Branco Award from the Portuguese Society of Diabetes and Lilly Portugal (to Silvia Conde and Maria Guarino)
There is an open call for applications for a Research Grant (BI), for the conduct of R&D activities by a PhD student or a graduate with a Bachelor’s or Master’s degree enrolled in a course non-leading to an academic degree, under reference SAI/2022/06 in the scope of the project EXPL/MED-NEU/0733/2021, at the institution Faculdade de Ciências Médicas|NOVA Medical School (FCM|NMS), Universidade NOVA de Lisboa (UNL), supported by income from the above mentioned project financed by the Fundação para a Ciência e a Tecnologia, I.P. (FCT, I.P.).
Application deadline: May 27 (until 5:00 PM), 2022.
Researchers from the Neuronal Control of Metabolic Disturbances lab published in Frontiers for Young Minds a review of existing knowledge about how our fat-accumulating cells evolve over time.
The research groups from Paula Macedo and Sílvia Conde made several presentations at the European Congress EASD 2022, which took place in Stockholm.
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