The Integrative Biomedicine Laboratory has a curiosity-driven, fundamental research program on animal neurophysiology using Drosophila as a model system and a goal-oriented, translational program focusing on disease modelling and cell targeting techniques for human cells.
In our curiosity-driven program, we rely heavily on genetic approaches, such as neurogenetics, targeted genome editing, and intersectional genetics to study pathways involved in interorgan communication events – typically between the central nervous system and peripheral organs.
In our translational program, we model human neurodegenerative disease and develop new tools for human cell type-specific treatments. Briefly, we use synthetic and computational biology to engineer new genetic tools for human cell type diagnosis and treatment. We are building genetic systems based on intersectional genetics concepts (developed and tested in Drosophila) and plan to test these systems directly on human organoids derived from our custom-engineered human induced pluripotent stem cell reporter lines.
Two other projects are also underway studying:
Os animais têm formas específicas de escapar ao perigo externo. E um estudo colaborativo releva agora que existem sinais promovidos por moléculas libertadas por neurónios para fazer com que larvas da mosca da fruta (Drosophila melanogaster) escapem de estímulos externos nocivos.
Current national collaborations
Current International collaborations
NOVA Medical SchoolCampo Mártires da Pátria, 1301169-056 LisboaPORTUGAL
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