CEDOC Campus Sant'Ana Pólo de Investigação, NMS, UNL Rua Câmara Pestana, nº 6 Lab 3.16 1150-082 Lisboa, Portugal
Telefone: 218803100

André R. A. Marques

Investigador Investigador Júnior
I am biochemist currently working at the Chronic Diseases Research Centre (CEDOC) of the NOVA University Lisbon (Portugal). I have a strong background in Biochemistry (BSc, University of Lisbon) and a keen interest in the biochemical pathways of human disease (MSc & PhD in Medical Biochemistry, University of Amsterdam, The Netherlands). During my PhD studies I investigated the role of lysosomal homeostasis in neurodegeneration. Afterwards, I developed a 3-year PostDoctoral Project at the University of Kiel (Germany) centered on Batten disease (NCL2TREAT, Consortium), the most common inherited neurodegenerative disease in children. In 2018, I was awarded the CEECIND contract by FCT to develop a project investigating the role of lysosomal dysfunction in atherosclerosis at CEDOC.
  • Di Spiezio, Alessandro; Marques, André R. A.; Schmidt, Lina; Thießen, Niklas; Gallwitz, Lisa; Fogh, Jens; Bartsch, Udo; Saftig, Paul. "Analysis of cathepsin B and cathepsin L treatment to clear toxic lysosomal protein aggregates in neuronal ceroid lipofuscinosis". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1867 10 (2021): 166205-166205. http://dx.doi.org/10.1016/j.bbadis.2021.166205.
  • Liliana S. Alves; André R. A. Marques; Nuno Padrão; Filomena A. Carvalho; José Ramalho; Catarina Lopes; Maria I. L. Soares; et al. "Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth muscle cells homeostasis". Journal of Cell Science (2021): https://doi.org/10.1242/jcs.254631. - Marques, André R. A.; Ramos, Cristiano; Machado-Oliveira, Gisela; Vieira, Otília V. "Lysosome (Dys)function in Atherosclerosis - A Big Weight on the Shoulders of a Small Organelle". Frontiers in Cell and Developmental Biology 9 (2021): 658995. https://www.frontiersin.org/articles/10.3389/fcell.2021.658995/full.
  • van der Lienden, Martijn JC; Aten, Jan; Marques, André R. A.; Waas, Ingeborg SE; Larsen, Per WB; Claessen, Nike; van der Wel, Nicole N; et al. "GCase and LIMP2 Abnormalities in the Liver of Niemann Pick Type C Mice". International Journal of Molecular Sciences 22 5 (2021): 2532. https://www.mdpi.com/1422-0067/22/5/2532.
  • Boer, Daphne E C; Mirzaian, Mina; Ferraz, Maria J; Zwiers, Kimberley C; Baks, Merel V; Hazeu, Marc D; Ottenhoff, Roelof; et al. "Human glucocerebrosidase mediates formation of xylosyl-cholesterol by ß-xylosidase and transxylosidase reactions.". Journal of lipid research (2020): https://doi.org/10.1194/jlr.
  • Machado-Oliveira, Gisela; Ramos, Cristiano; Marques, André R. A.; Vieira, Otília V. "Cell Senescence, Multiple Organelle Dysfunction and Atherosclerosis.". Cells (2020): https://europepmc.org/articles/PMC7598292.
  • Herrera Moro Chao, Daniela; Wang, Yanan; Foppen, Ewout; Ottenhoff, Roelof; van Roomen, Cindy; Parlevliet, Edwin T.; van Eijk, Marco; et al. "The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1". Diabetes 68 12 (2019): 2223-2234. http://dx.doi.org/10.2337/db19-0049.
  • Marques, André R. A.; Alessandro Di Spiezio; Niklas Thießen; Lina Schmidt; Joachim Grötzinger; Renate Lüllmann-Rauch; Markus Damme; et al. "Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis". Autophagy (2019): 1-15. https://doi.org/10.1080/15548627.2019.1637200.
  • Marques, André R. A.; Saftig, Paul. "Lysosomal storage disorders - challenges, concepts and avenues for therapy: beyond rare diseases". Journal of Cell Science 132 2 (2019): jcs221739. http://dx.doi.org/10.1242/jcs.221739.