Edifício CEDOC II, Rua Câmara Pestana n.º 6
Telefone: 218803132 Ext: 26092

Diogo Miguel Barros Bitoque

Investigador  Investigador Doutorado
Diogo Bitoque has a PhD in Mechanisms of Disease and Regenerative Medicine and is currently working in the Gene Therapy lab in the project entitled TARGET - TArgeting diabetic Retinopathy with GEne Therapy
• Oliveira AV, Silva AP, Bitoque D, Silva GA, Rosa da Costa AM; Transfection efficiency of chitosan and thiolated chitosan in retinal pigment epithelium cells: A comparative study; Journal of Pharmacy And Bioallied Sciences; 2013; 5; 111-118. • Machado S, Calado S, Bitoque D, Oliveira AV, Opstad CL, Zeeshan M, Sliwka HR, Partali V, Pungente MD, Silva GA; Cationic polyene phospholipids as DNA carriers for ocular gene therapy; BioMed Research International, Volume 2014, Article ID 703253, 13 pages. • Oliveira AV, Bitoque D and Silva GA; Combining Hyaluronic Acid with Chitosan Enhances Gene Delivery; Journal of Nanomaterials, Volume 2014, Article ID 246347, 9 pages. • Simão S, Bitoque D, Calado SM, Silva GA (2016) Oxidative stress modulates the expression of VEGF isoforms in the diabetic retina; New Front Ophthalmol2: doi: 10.15761/NFO.1000119. • Bitoque D, Simão S, Oliveira AV, Machado S, Duran MR, Lopes E, da Costa AMR, and Silva GA.; Efficiency of RAFT-synthesized PDMAEMA in gene transfer to the retina; J Tissue Eng Regen Med, 11: 265–275, 2017. doi: 10.1002/term.1909. • Bitoque D, da Costa AMR, Silva GA. Insights on the intracellular trafficking of PDMAEMA gene therapy vectors; Materials Science & Engineering C- Materials for Biological Applications, Volume 93, 1 December 2018, Pages 277-288, doi: 10.1016/j.msec.2018.07.071. • Bitoque D, Silva GA. Molecular biology tools for the study and therapy of Retinitis Pigmentosa; Journal of Biotechnology, Volume 284, 20 October 2018, Pages 1-5, doi: 10.1016/j.jbiotec.2018.07.030. • Machado M, Silva GA, Bitoque D, Ferreira J, Pinto LA, Morgado J, Ferreira Q. Self-Assembled Multilayer Films for Time-Controlled Ocular Drug Delivery; ACS Applied Bio Materials 2019, 2 (10), 4173-4180, doi: 10.1021/acsabm.9b00417. • Pires F, Santos JF, Bitoque D, Silva GA, Marletta A, Nunes VA, Ribeiro PA, Silva JC, Raposo M. Polycaprolactone/Gelatin Nanofiber Membranes Containing EGCG-Loaded Liposomes and Their Potential Use for Skin Regeneration; ACS Applied Bio Materials 2019, 2 (11), 4790-4800, doi: 10.1021/acsabm.9b00524. • Araújo RS, Bitoque D, Silva GA. Dual-Acting Antiangiogenic Gene Therapy Reduces Inflammation and Regresses Neovascularization in Diabetic Mouse Retina; Molecular Therapy Nucleic Acids 2020, Volume 22, 4 December 2020, Pages 329-339, doi: 10.1016/j.omtn.2020.08.036. • Bitoque D, Morais J, Oliveira AV, Sequeira RL, Calado SM, Fortunato TM, Simão S, da Costa AMR, Silva GA. Human-derived NLS enhance the gene transfer efficiency of chitosan; Bioscience Reports 2021, 41 (1), doi.org/10.1042/BSR20201026. • Araújo RS, Bitoque D, Silva GA. Development of Strategies to Modulate Gene Expression of Angiogenesis-related Molecules in the Retina; Gene, Volume 791, July 2021, 145724; https://doi.org/10.1016/j.gene.2021.145724. • Almeida AC, Bitoque D, Martins C, Coelho C, Borrego LM, Silva GA. Serum levels of Placental Growth Factor reflect the severity of Retinopathy of Prematurity; Acta Paediatrica; https://doi.org/10.1111/apa.15976.
Ciência ID: D81C-6457-7F28