Edifício CEDOC II, Room 2.28. Rua Câmara Pestana n.º 6, 6-A 1150-082 Lisboa. PORTUGAL
Telefone: 218803102 Ext: 26033

José António Belo

Docente Professor Associado com Agregação
José Belo is an Associate Professor at NOVA Medical School/Universidade NOVA de Lisboa (NMS/UNL) where he is also the Coordinator of the Animal Facility. He teaches, and is the course director, of Molecular and Cellular Biology, Developmental Biology, Stem Cells and Development and New Cellular and Molecular Therapies. He is a Principal Investigator at Centro de Estudos de Doenças Crónicas (CEDOC/NMS) where he is the head of the Stem Cells and Development Lab. We focus our studies on the induction and control of myocardium and coronary vasculature’s development, organogenesis and function. The Belo´s lab has been using the most up to date technologies in molecular embryology and regenerative medicine. Those include generation and analysis of KO mouse lines, mouse and human ES/iPS cell differentiation and CRISPR/CAS9 technologies. We aim to understand the aetiology and treatment of Cardio-Vascular Disease, from a Developmental Biology, Genetics and Physiology perspective, with Regenerative Medicine purposes.
Recent 5 year's most relevant publications: - José Manuel Inácio, João von Gilsa Lopes, Ana Mafalda Silva, Fernando Cristo, Sara Marques, Matthias E. Futschik, José António Belo (2021). DAND5 inactivation promotes cardiac differentiation in mouse embryonic stem cells. Front. Cell Dev. Biol. doi: 10.3389/fcell.2021.629430. - José M. Inácio, Micael Almeida, Fernando Cristo and José A. Belo (2019). Generation of gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c.455G>A alteration in DAND5. Stem Cell Research. doi.org/10.1016/j.scr.2019.101677. - Bover O, Justo T, Pereira PNG, Facucho-Oliveira J, Inácio JM, Ramalho JS, Domian IJ, Belo JA (2018). Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells. PLoS One. 2018 Oct 3;13(10):e0205108. doi: 10.1371/journal.pone.0205108. eCollection 2018. - Bonet F, Pereira PNG, Bover O, Marques S, Inácio JM, Belo JA (2018). CCBE1 is required for coronary vessel development and proper coronary artery stem formation in the mouse heart. Dev Dyn. 247:1135–1145. 2018 Sep 11. doi: 10.1002/dvdy.24670. - Silva MM, Gomes-Alves P, Rosa S, Simão D, Inácio JM, Peixoto C, Serra M, Belo JA, Alves PM. (2018). Full-length human CCBE1 production and purification: leveraging bioprocess development for high quality glycosylation attributes and functionality. J Biotechnol. 2018 Aug 27;285:6-14. doi: 10.1016/j.jbiotec.2018.08.015. 0.1016/j.scr.2018.04.015. - José A. Belo, Sara Marques and José M. Inácio (2017). The Role of Cerl2 in the Establishment of Left-Right Asymmetries during Axis Formation and Heart Development. J. Cardiovasc. Dev. Dis. 2017, 4, 23; Doi:10.3390/jcdd4040023. - Fernando Cristo, José M. Inácio, Graça Rosas, Isabel Marques Carreira, Joana Barbosa Melo, Luís Pereira de Almeida, Patrícia Mendes, Duarte Saraiva Martins, José Maio, Rui Anjos and José A. Belo (2017). Generation of human iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alteration. Stem Cell Research 25:152-156. DOI: 10.1016/j.scr.2017.10.19. - Fernando Cristo, José M. Inácio, Salomé de Almeida, Patrícia Mendes, Duarte Saraiva Martins, José Maio, Rui Anjos and José A. Belo (2017). Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects. BMC Medical Genetics. 18(1):77. DOI : 10.1186/s12881-017-0444-1.
ORCID: 0000-0001-7384-0949 ResearcherID: F-4444-2012 Ciencia ID: BF13-08E9-25E6