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NOVA Medical School - Grey Building | Rua Câmara Pestana 6, 1150-199 Lisboa, Portugal

Paulo Gameiro

Researcher Investigador Principal
Principal Investigator

Paulo Gameiro became deeply curious about metabolism and evolution early on, when learning that cells rely on small molecules to sustain life in a remarkably regulated and conserved manner. This led him to study biochemistry, and later central carbon metabolism, RNA biology and mitochondria. His group uses bottom-up approaches to integrate metabolic components and their interactions, aiming to understand mitochondrial pathophysiology from the ground up.

RESEARCH ARTICLES:

  • Gameiro PA*, Foskolou IP*, Butt YA, Martens A, Kuret K, de los Mozos IR, Zandhuis ND, Hozjan Ž, Kot V, Faraway R, Vermeulen M, Wolkers M, Johnson RS, Ule J. (2026). Meta-unstable mRNAs in activated CD8+ T cells are defined by interlinked AU-rich elements and m6A mRNA methylation. | * Equal contribution. Nat Communications 17, 160 (2026). https://doi.org/10.1038/s41467-025-67762-w
  • Santos CC, Schweizer N, Cairrão F, Ramirez J, Osinalde N, Yang M, Gaspar CJ, Rasheva VI, Hensel Z, Adrain C, Cordeiro TN, Voigt F, Gameiro PA, Mayor U, Domingos PM (2025). Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling. Nature Communications 16(1):7523. doi: 10.1038/s41467-025-62417-2.
  • Barbieri L, Veliça P, Gameiro PA, Cunha PP, Foskolou IP, Rullman E, Bargiela D, Johnson RS, and Rundqvist, H. (2023). Lactate exposure shapes the metabolic and transcriptomic profile of CD8+ T cells. Frontiers in Immunology, 14. doi: 10.3389/fimmu.2023.1101433
  • Gameiro PA ¶, Encheva V, Dos Santos MS, MacRae JI, and Ule J. (2021). Metabolic turnover and dynamics of modified ribonucleosides by 13C labelling. Journal of Biological Chemistry 297(5):101294. | ¶ Corresponding author. doi: 10.1016/j.jbc.2021.101294
  • Rundqvist H, Veliça P, Barbieri L, Gameiro PA, Bargiela D, Gojkovic M, Mijwel S, Reitzner SM, Wulliman D, Ahlstedt E, Ule J, Östman A, and Johnson RS. (2020). Cytotoxic T-cells mediate exercise-induced reductions in tumor growth. Elife 9. doi: 10.7554/eLife.59996
  • Gameiro PA and Struhl K. (2018). Nutrient deprivation elicits a transcriptional and translational inflammatory response coupled to decreased protein synthesis. Cell Reports 24(6):1415-1424. doi: 10.1016/j.celrep.2018.07.021 | Comment in Trends Biochem Sci 43 (11), 849-852 ‘Translation Links Nutrient Availability with Inflammation’. doi: 10.1016/j.tibs.2018.08.010
  • Okazaki A, Gameiro PA, Christodoulou D, Laviollette L, Schneider M, Chaves F, Stemmer-Rachamimov A, Yazinski SA, Lee R, Stephanopoulos G, Zou L, and Iliopoulos O. (2017). Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers. Journal of Clinical Investigation. 127(5): 1631–1645. doi: 10.1172/JCI87800 | Comment in Nat Rev Nephrol 13 (6), 320 ‘Kidney Cancer: Targeting Metabolism in RCC’. doi: 10.1038/nrneph.2017.57
  • Gameiro PA, Yang J, Metelo AM, Pérez-Carro R, Baker R, Wang Z, Arreola A, Rathmell WK, Olumi A, López-Larrubia P, Stephanopoulos G, and Iliopoulos O. (2013). In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation. Cell Metabolism 17(3):372-85. doi: 10.1016/j.cmet.2013.02.002 | Comment in Nat Rev Cancer 13 (5), 293 ‘Metabolism: Glutamine connections’. doi: 10.1038/nrc3515
  • Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, and Stephanopoulos G. (2013). Cofactorbalance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylationand glucose catabolism in the TCA cycle. Journal of Biological Chemistry 288(18):12967-77. doi:10.1074/jbc.M112.396796 | Paper of the week
  • Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, and Stephanopoulos G. (2012). Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 481 (7381):380-4. doi: 10.1038/nature1060

SELECTED BOOK CHAPTERS:

  • Patrício JS*, Mendes*, and Gameiro PA. Mitochondrial energy metabolism in cancer, immunoregulation and anti-tumour response. Springer Nature 2025. In press. *Equal contribution
    Patrício JS, Guerreiro ACL*, Gameiro PA*, and Morello J*. Mass spectrometry as a tool for metabolomics in cancer. Springer Nature 2025. In press. *Equal contribution

PATENT:

  • (2018) Metabolic Gene, Enzyme, and Flux Targets for Cancer Therapy (US Patent No. US10064885B2).
    Inventors: Stephanopoulos G, Metallo CM, Kelleher JK, Iliopoulos O
  • 2014 | InnoCentive Award: “Real Time Monitoring of Steroid Metabolites and Metabolic Flux”
  • 2008 | Sc top3% merit prize, University of Coimbra, Portugal
  • 2007 | BSc top3% merit prize, University of Coimbra, Portuga
  • 2006 | BSc merit prize, BPI bank, Portugal