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Location

Rua Câmara Pestana n.º 6 1150-082 Lisboa
Phone: 218803127

Gabriela Araújo Silva

Professor Professor Associado com Agregação
Principal Investigator

Gabriela Silva is an Associate Professor in Biomedicine, with teaching duties on the MSc in Medicine, BSc in Nutrition Sciences and PhD programmes in Medicine, Biomedicine and Health Sciences, She also serve in the institutional Animal Welfare Body (ORBEA) and Ethics Committee. Other functions include coordinating students' assessment.
Her research is focused on gene therapy for retinal diseases. She has a broad background in biology, biomaterials and molecular genetics, being a PI of several national- and international-funded grants with active collaborations with other researchers in funded projects.

  • D.B. Bitoque, G.A. Silva. Molecular biology tools for the study and therapy of PDE6beta mutations. Journal of Biotechnology, 284, pp 1-5. https://doi.org/10.1016/j.jbiotec.2018.07.030.
  • R.S Araújo, M.S. Silva, D.F. Santos, G.A. Silva. Dysregulation of trophic factors contributes to diabetic retinopathy in the Ins2Akita mouse. Experimental Eye Research. Vol 194. May 2020, 108027. https://doi.org/10.1016/j.exer.2020.108027.
  • R.S. Araújo, D.B. Bitoque, G.A. Silva. Dual-acting antiangiogenic gene therapy reduces inflammation and regresses neovascularization in diabetic mouse retina. Molecular Therapy. 2020; 22:329.339. doi: 10.1016/j.omtn.2020.08.036.
  • D.B. Bitoque*, J. Morais*, A.V. Oliveira*, S. Simão, T.M. Fortunato, S.M. Calado, R. Sequeira, A.M Rosa da Costa, G.A. Silva. Human-derived NLS enhance nonviral transfection. Bioscience Reports. 2021. 41(1). doi:10.1042/BSR20201026. *Equal contribution.
  • R.S. Araújo, D.B. Bitoque, G.A. Silva. Development of Strategies to Modulate Gene Expression of Angiogenesis-related Molecules in the Retina. Gene 791, 145724. https://doi.org/10.1016/j.gene.2021.145724.
  • A.M.L. Oliveira, M. Machado, G.A. Silva, D.B. Bitoque, J. Ferreira, L.A. Pinto, Q. Ferreira. Graphene Oxide Thin Films with Drug Delivery Function. Nanomaterials 2022, 12(7), 1149. doi: 10.3390/nano12071149.
  • D.B. Bitoque*, C. Fernandes*, A.M.L. Oliveira, G.A. Silva. Strategies to improve the targeting of retinal cells by gene therapy vectors . Frontiers in Drug Delivery. *Equally contributing authors. doi: 10.3389/fddev.2022.899260.
  • S. Talebin, B. Mendes, J. Conniot, D.B. Bitoque, G.A.Silva, J. Conde, G.G. Wallace. Biopolymeric coatings for local release of therapeutics from biomedical implants. Advanced Science. Impact factor: 17.52. https://doi.org/10.1002/advs.202207603.
  • D.B. Bitoque, S.M. Calado, A.M. Rosa da Costa, G.A. Silva. PDMAEMA gene vectors efficiently express PDE6β in a mouse model of retinitis pigmentosa. Biorxiv. https://www.biorxiv.org/content/10.1101/2023.05.04.538567v1.
  • F. Serdoura Alves; S. Duarte; A. Cabrita; C. Marques; A. Oliveira; M. Machado; G.A. Silva; L. Abegão Pinto; J. Tavares Ferreira; Q. Ferreira. Nanotechnology Devices for Glaucoma Surgical Treatment: A Systematic Review. Journal of Vision. (deposited in Preprints 2023, 2023091935. https://doi.org/10.20944/preprints202309.1935.v1
  • 2015: Travel Award for best podium communications, awarded to the following paper: S.M. Calado, L. Alves, G.A. Silva. Hyperglycemia and hypoxia induce overexpression of GLUT1 in models of diabetic retinopathy. EASD Annual Meeting 2015, Stockholm, September 2015.
  • 2016: Janssen Innovation Award 2016: Honorable mention for the paper "Aliskeren as a new therapeutic approach for the treatment of diabetic retinopathy."
  • 2018: Best Poster Award, awarded to the following paper: D.F. Santos, M. Pais, C.S. SANTOS, G. A. Silva. Can (poly)phenol metabolites ameliorate the outcome of diabetic retinopathy?. 2nd International Conference on Food Bioactives and Health, Portugal, 2018. Poster presentation.
  • 2019: Poster presentation entitled: "Characterization and Modulation of the Renin-Angiotensin System: Towards a New Therapy for Diabetic Retinopathy," by Brigite Cabrita, D.F. SANTOS, G.A. Silva, selected as a finalist in the iMed 11.0(R) Innovation Contest.
  • 2020: Best Oral Presentation Award for R. Araújo, G.A. Silva, "Dual Gene Therapy Approach for the Treatment of Diabetic Retinopathy." National Meeting of the Brazilian Society of Diabetology. 2020.
  • 2020: Dr. Almeida Ruas Award, Best Clinical Project. G.A. Silva, "Analysis of Systematic Levels of Angiogenic and Antiangiogenic Factors in Diabetic Retinopathy." Brazilian Society of Diabetology. 2020.
  • 2022: Louvor nº46/2022, Faculdade de Ciências Médicas, Universidade Nova de Lisboa.
  • ORCID: 0000-0001-5946-1918
  • CIÊNCIA ID: DC1E-F164-FDD92