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Francisco Esteves

Professor Professor Auxiliar
Assistant Professor
Graduated in Biotech Eng (2003), PhD in Biomedical Sciences (2010), Postdocs in Microbiology and Infectious Diseases (2012-2015) and Xenobiotic Metabolism and Toxicogenomics (2016-2018). Since 2019, Researcher at the Xenobiotic Metabolism lab, ToxOmics, BioMedicin (NMS|FCM, UNL).
  • ESTEVES F, RUEFF J, KRANENDONK M. (2021). The Central Role of Cytochrome P450 in Xenobiotic Metabolism—A Brief Review on a Fascinating Enzyme Family. J Xenobiot, 11(3):94-114. (doi: 10.3390/jox11030007).
  • SILVEIRA CM, RODRIGUES PR, GHACH W, PEREIRA SA, ESTEVES F, KRANENDONK M, ETIENNE M, ALMEIDA MG. (2021). Electrochemical Activity of Cytochrome P450 1A2: The Relevance of O2 Control and the Natural Electron Donor. ChemElectroChem, 8, 500. (doi: 10.1002/celc.202001255).
  • ESTEVES F, URBAN P, RUEFF J, TRUAN G, KRANENDONK M. (2020). Interaction Modes of Microsomal Cytochrome P450s with Its Reductase and the Role of Substrate Binding. Int J Mol Sci, 21(18):6669. (doi: 10.3390/ijms21186669).
  • ESTEVES F, CAMPELO D, GOMES BC, URBAN P, BOZONNET S, LAUTIER T, RUEFF J, TRUAN G, KRANENDONK M. (2020). The Role of the FMN-Domain of Human Cytochrome P450 Oxidoreductase in Its Promiscuous Interactions With Structurally Diverse Redox Partners. Front Pharmacol, 11:299. (doi: 10.3389/fphar.2020.00299).
  • MATOS OMG, CARDOSO FMH, ESTEVES F, CHOCALHEIRO AL. Antigénio recombinante sintético de Pneumocystis jirovecii e sua aplicação no diagnóstico serológico da pneumonia por P. jirovecii (PPc) ou pneumocistose, PT109078 [Ref. DP/01/2020/71552 (A61K 39/395)], submission 01-11-2016, concession 15-04-2020. (Patent).
  • CAMPELO D, ESTEVES F, BRITO PALMA B, COSTA GOMES B, RUEFF J, LAUTIER T, URBAN P, TRUAN G, KRANENDONK M. (2018). Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450. Int J Mol Sci, 6;19(12). (doi: 10.3390/ijms19123914).
  • ESTEVES F, CAMPELO D, URBAN P, BOZONNET S, LAUTIER T, RUEFF J, TRUAN G, KRANENDONK M. (2018). Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4. Biochemical Pharmacology, 158:134-140. (doi: 10.1016/j.bcp.2018.10.006).
  • CAMPELO D, LAUTIER T, URBAN P, ESTEVES F, BOZONNET S, TRUAN G, KRANENDONK M. (2017). The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength. Front Pharmacol, 8:755. (DOI: 10.3389/FPHAR.2017.00755).
  • MATOS O, ESTEVES F. (2016). Laboratoty diagnosis of Pneumocystis jirovecii pneumonia - Chapter 13. In K. Kon & M. Rai (Eds.), The Microbiology of Respiratory System Infections, 1st Edition (pp. 185-210). Kidlington, Oxford: Elsevier, Inc. (Book chapter).
  • TOMÁS AL, CARDOSO F, ESTEVES F, MATOS O. (2016). Serological diagnosis of pneumocystosis: production of a synthetic recombinant antigen for immunodetection of Pneumocystis jirovecii. Scientific Reports–Nature, 6:36287. (doi: 10.1038/SREP36287).
  • ESTEVES F, DE SOUSA B, CALDERÓN EJ, HUANG L, BADURA R, MALTEZ F, BASSAT Q, DE ARMAS Y, ANTUNES F, MATOS O. (2016). Multicenter study highlighting clinical relevance of new high-throughput methodologies in molecular epidemiology of Pneumocystis jirovecii pneumonia. Clinical Microbiology and Infection, 22(6):566.e9-566.e19. (doi: 10.1016/j.cmi.2016.03.013).
  • Research Travel Grant Tebu-bio (2017) for participation in the 20th International Conference on Cytochrome P450: Biochemistry, Biophysics and Biotechnology, Heinrich-Heine University (Düsseldorf, Germany, 2017).
  • 1st Place award – 4th Workshop NOVA SAÚDE – Genética”, Rectory of the UNL, Poster presentation – “The role of Progesterone Receptor Membrane Component 1 (PGRMC1) in cytochromes P450 (CYP)-mediated Xenobiotic metabolism” (2019) (co-author).
  • 1st Place award – 2nd Workshop NOVA SAÚDE – Genética”, Rectory of the UNL, Poster presentation – “The importance of hinge and FMN genetic variants of NADPH cytochrome P450 oxidoreductase” (2016) (co-author).
  • 2nd Place award – 7as Jornadas de Actualização em Doenças Infecciosas do Hospital de Curry Cabral, Poster presentation – “Múltiplas infecções oportunistas num doente infectado por VIH: armas de um sucesso clínico” (2010) (co-author).
  • Conference award grant (Ref. R13 AI078718) from the USA National Institute of Allergy and Infectious, NIH, U. S. Department of Health & Human Services (2008), for the participation in the X International Workshops on Opportunistic Protists (IWOP-10), organized by the International Society of Protistologists (ISP) (Boston, Massachusetts, USA) (2008).
  • ORCID ID: ORCID.ORG/0000-0002-3046-1313
  • Scopus Author ID: 35306794500 (FCT)
  • Ciência ID: 7913-2CCE-CACC