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Location

Rua Câmara Pestana n.º 6, 6-A 1150-082 Lisboa. PORTUGAL

José António Belo

Professor Professor Catedrático
Principal Investigator

José António Belo is a Full Professor of Cellular and Molecular Biology at NOVA Medical School, from NOVA University Lisbon, where he is also the Coordinator of the PhD Program ProRegeM. He teaches, and is the course director of Cellular and Molecular Biology-MIM, Developmental Biology and Stem Cells and Development.

He is currently the Executive Director for the Research Support Structure, where also leads the Stem Cells and Development Lab within the research unit, iNOVA4Health, at NOVA Medical School. 

His group studies focus on the induction and control of myocardium and coronary vasculature’s development, organogenesis and function, using the most up to date technologies in molecular embryology and regenerative medicine. Those include generation and analysis of KO mouse lines, mouse and human ES/iPS cell differentiation and CRISPR/CAS9 technologies. The aim is to understand the aetiology and treatment of Cardio-Vascular Disease, from a Developmental Biology, Genetics and Physiology perspective, with Regenerative Medicine purposes.

José Belo is a founding member of the Portuguese Society of Stem Cells-Cell Therapy (SPCE-TC), from which he is currently the Chairman of the General Assembly.

Recent 5 year's most relevant publications:

  • José Manuel Inácio, João von Gilsa Lopes, Ana Mafalda Silva, Fernando Cristo, Sara Marques, Matthias E. Futschik, José António Belo (2021). DAND5 inactivation promotes cardiac differentiation in mouse embryonic stem cells. Front. Cell Dev. Biol. doi: 10.3389/fcell.2021.629430.
  • José M. Inácio, Micael Almeida, Fernando Cristo and José A. Belo (2019). Generation of gene-corrected human induced pluripotent stem cell line derived from a patient with laterality defects and congenital heart anomalies with a c.455G>A alteration in DAND5. Stem Cell Research. doi.org/10.1016/j.scr.2019.101677.
  • Bover O, Justo T, Pereira PNG, Facucho-Oliveira J, Inácio JM, Ramalho JS, Domian IJ, Belo JA (2018). Loss of Ccbe1 affects cardiac-specification and cardiomyocyte differentiation in mouse embryonic stem cells. PLoS One. 2018 Oct 3;13(10):e0205108. doi: 10.1371/journal.pone.0205108. eCollection 2018.
  • Bonet F, Pereira PNG, Bover O, Marques S, Inácio JM, Belo JA (2018). CCBE1 is required for coronary vessel development and proper coronary artery stem formation in the mouse heart. Dev Dyn. 247:1135–1145. 2018 Sep 11. doi: 10.1002/dvdy.24670.
  • Silva MM, Gomes-Alves P, Rosa S, Simão D, Inácio JM, Peixoto C, Serra M, Belo JA, Alves PM. (2018). Full-length human CCBE1 production and purification: leveraging bioprocess development for high quality glycosylation attributes and functionality. J Biotechnol. 2018 Aug 27;285:6-14. doi: 10.1016/j.jbiotec.2018.08.015. 0.1016/j.scr.2018.04.015.
  • José A. Belo, Sara Marques and José M. Inácio (2017). The Role of Cerl2 in the Establishment of Left-Right Asymmetries during Axis Formation and Heart Development. J. Cardiovasc. Dev. Dis. 2017, 4, 23; Doi:10.3390/jcdd4040023.
  • Fernando Cristo, José M. Inácio, Graça Rosas, Isabel Marques Carreira, Joana Barbosa Melo, Luís Pereira de Almeida, Patrícia Mendes, Duarte Saraiva Martins, José Maio, Rui Anjos and José A. Belo (2017). Generation of human iPSC line from a patient with laterality defects and associated congenital heart anomalies carrying a DAND5 missense alteration. Stem Cell Research 25:152-156. DOI: 10.1016/j.scr.2017.10.19.
  • Fernando Cristo, José M. Inácio, Salomé de Almeida, Patrícia Mendes, Duarte Saraiva Martins, José Maio, Rui Anjos and José A. Belo (2017). Functional study of DAND5 variant in patients with Congenital Heart Disease and laterality defects. BMC Medical Genetics. 18(1):77. DOI : 10.1186/s12881-017-0444-1.
  • ORCID: 0000-0001-7384-0949
  • ResearcherID: F-4444-2012
  • Ciencia ID: BF13-08E9-25E6