Nutrition: Clinical Research

Our research aims to identify, to understand and to evaluate how health and disease are influenced by nutrition. 

We develop collaborative projects in health, food and sport sectors establishing therefore partnerships with hospitals, health units, pharmaceutic industry, clinical associations, sport federations, among other partners. We explore food behaviour as well as food consumption and ingestion of specific nutrients or food supplements aiming to improve metabolic outcomes and to create new preventive interventions to reduce the risk of chronic diseases.

Graphical Abstract
  • ClinicalTrials.gov ID: NCT02975856 - Bioavailability of Red Wine Anthocyanins.
    (https://clinicaltrials.gov/ct2/show/study/NCT02975856?term=calhau&draw=2&rank=7)

    Anthocyanins (ANT) are water soluble pigments found in plants, flowers and fruits that are consumed as part of the human diet, many times in higher amounts than other flavonoid classes. Red wine is also an important source of anthocyanins, especially Mv3glc.
    Several epidemiological studies have suggested that the consumption of anthocyanin-rich foods, including the moderate consumption of red wine, is positively associated with the prevention of cardiovascular heart disease.
    It has become clear that the flavonoid bioactive forms in vivo are not necessarily those which occur in nature, but metabolites arising after absorption takes place.Therefore, studying the bioavailability of red wine ANT is very important to identify which metabolites (originated in vivo) can actually reach the target organs (and in which concentrations) and may be responsible for the postulated health benefits of red wine.

Publication:
“Pharmacokinetics of table and Port red wine anthocyanins: a crossover trial in healthy men.”Fernandes I, Marques C, Évora A, Cruz L, de Freitas V, Calhau C, Faria A, Mateus N, Food & Function, 2017, 8, 2030-2037.

  • ClinicalTrials.gov ID: NCT02613715 - Bioavailability of Blackberry Juice Anthocyanins.
    (https://clinicaltrials.gov/ct2/show/NCT02613715?term=calhau&draw=2&rank=8)

    Anthocyanins (ANT), a particular class of flavonoids that can be found in red wine and red fruits, have been associated with relevant health benefits. It has become clear that the flavonoid bioactive forms in vivo are not necessarily those which occur in nature, but metabolites arising from them after absorption. Therefore, it is important to identify which ANT metabolites are responsible for their health benefits. Since ANT can prevent/treat some of the metabolic features of obesity it is also crucial to study whether ANT bioavailability is not compromised in obesity.

Publication:
“Pharmacokinetics of blackberry anthocyanins consumed with or without ethanol: a randomized and crossover trial” Marques C, Fernandes I, Norberto S, Sá C, Teixeira D, de Freitas V, Mateus N, Calhau C, Faria A, Molecular Nutrition and Food Research, 2016, 60, 11, 2319-2330.

  • ClinicalTrials.gov Identifier: NCT02608138 - Iogeneration
    It is well known that insufficient iodine intakes impairs the production of thyroid hormones, essential for cognitive development and healthy growth.
    Although the World Health Organization (WHO) promotes public health measures for an adequate iodine consumption, it is estimated that one in three school age children remain iodine deficient worldwide. Whereas there is no mandatory iodisation programs in Portugal, young infants are among the most vulnerable to iodine deficiency due to their special requirements.
    Therefore, the present study aims to evaluate iodine status in school age Portuguese children (6-12y), compare iodine status in children, cognitive outcomes and thyroid health and monitor the use of iodised salt in school canteens exploring potential implications in children's iodine status.

Publication:
Iodine Status and Iodised Salt Consumption in Portuguese School-Aged Children: The Iogeneration Study. Costa Leite J, Keating E, Pestana D, Cruz Fernandes V, Maia ML, Norberto S, Pinto E, Moreira-Rosário A, Sintra D, Moreira B, Costa A, Silva S, Costa V, Martins I, Castro Mendes F, Queirós P, Peixoto B, Carlos Caldas J, Guerra A, Fontoura M, Leal S, Moreira R, Palmares Carvalho I, Matias Lima R, Martins C, Delerue-Matos C, Almeida A, Azevedo L, Calhau C. Nutrients. 2017 May 5;9(5):458.

 

2021

  • DUOBETES: Screening for new high potential therapeutic targets in duodenum against type 2 diabetes – Fundação para a Ciência e Tecnologia EXPL/MED-PAT/0852/2021
  • MONET: Unravelling Microbiota-gut-brain axis paintings in obesity-associated Neuroinflammation: the blackbErry signaTure study – Fundação para a Ciência e Tecnologia PTDC/BAA-AGR/7419/2020 

2021

  • RESTART Project – An intervention study based on the microbiota and adipocyte-centric view to improve the success of bariatric surgery - Projetos de Investigação Clínica 2021, CUF Academic Center
  • Projeto Mobilizador - cLabel+: Alimentos inovadores “clean label” naturais, nutritivos e orientados para o consumidor 

2019

  • IoMum-Iodine status Monitoring in PortUguese pregnant woMen: impact of supplementation. 

2017

  • MOBFOOD – “Mobilização de conhecimento científico e tecnológico em resposta aos desafios do mercado agroalimentar” 024524 - LISBOA-01-0247-FEDER-024524 

2018

  • DIABEER – “Estudo aleatório do efeito da cerveja sem álcool no controlo glicémico de diabéticos tipo 2”
  • Effect of a Multi-component Education Program on Salt Reduction in Adults. Investigadores Principais. 2018-2019.
  • Nutrition attitudes and knowledge improvement in Portuguese medical students after completion of an integrated nutrition curricular unit. Investigadora Responsável (on going).
  • Vitamin D and Endocrine Disruptors relationship in Breast Cancer Women//Relação entre vitamina D e desreguladores endócrinos em mulheres com cancro da mama.
  • 13736 QREN - SI I&DT: MYRTILLUS – Mirtilos com inovação.
  • 138861 QREN - SI I&DT: VALORINTEGRADOR
  • P2020 – 3466 (2016-2018) “FUNCTIONALTUNA” - Desenvolvimento de conservas de atum funcionais
  • PTDC/AGR-TEC/2227/2012 - VINOFLAVO - Flavonoides do vinho tinto: biodisponibilidade e propriedades biológicas.
  • Projetos financiados pelo Espaço Económico Europeu EEa Grants. Programa de iniciativas em saúde pública – 153NU2. IoGeneration – Iodine status in Portugal (Estado do iodo em Portugal – papel da suplementação em idades escolares) 

2017

  • Research Grant from the Food and Health Programme, Faculty of Medical and Health Sciences, University of Auckland – Effect of circulating amino acids in insulin sensitivity following weight loss: a substudy of the PREVIEW study.

 

Clinical trials ID:

  • ClinicalTrials.gov ID: NCT03340259 - Intestinal Colonization in Newborn Infants With Enterostomy.
  • ClinicalTrials.gov ID: NCT03746093 - Effects of Non-alcoholic Beer in Patients With Type 2 Diabetes (DIABEER).
  • ClinicalTrials.gov ID: NCT03513432 - Influence of Beer on Gut Microbiota and Biochemical Outcomes: Alcohol Impact.
  • ClinicalTrials.gov ID: NCT02975856 - Bioavailability of Red Wine Anthocyanins.
  • ClinicalTrials.gov ID: NCT02613715 - Bioavailability of Blackberry Juice Anthocyanins.
  • ClinicalTrials.gov ID: NCT02608138 - Iodine Status in Portuguese Children and the Role of Salt Fortification in School Canteens (IoGeneration)
  • ClinicalTrials.gov ID: NCT02405507 - The Effect of Wheat Germ on Gastrointestinal Discomfort, Blood Cholesterol and Postprandial Glycaemic Response.
  • ClinicalTrials.gov ID: NCT03742492 - Bioavailability of EPA + DHA Enriched Canned Tuna and Its Acute Effects.
  • ClinicalTrials.gov ID: NCT04010708 - Iodine Status Monitoring in PortUguese Pregnant woMen: Impact of Supplementation (IOMUM).
  • ClinicalTrials.gov ID: NCT03830021 - Effect of a Multi-component Education Program on Salt Reduction in Adults.
  • ClinicalTrials.gov ID: NCT03663556 - Feeding the Preterm Gut Microbiota - Impact of Infant-feeding on Preterm Gut Microbiota Development (FEEDMI).
  • ClinicalTrials.gov ID: NCT04192357 - A Randomised Controlled Trial of a Weight Loss Maintenance Program forAdults With Obesity.
  • ClinicalTrials.gov ID: NCT04355741 - Gut Microbiota, "Spark and Flame" of COVID-19 Disease
  • ClinicalTrials.gov ID: NCT04370808 - VITACOV: Vitamin D Polymorphisms and Severity of COVID-19 Infection 

Durão C, Vaz C, Novaes de Oliveira V, Calhau C.  Obes Surg 2021. 10.1007/s11695-021-05608-2 [in press].

Moreira-Rosário A et al. Front. Microbiol, 19 2021.

Morais J et al. Nutrients. 2021  6;13(5):1564. 

Pinheiro, C. British Journal of Nutrition, 2021.1-9.

Ismael S et al. Nutrients. 2021. 8;13(4):1228.

Martins VS et al.  Clin Nutr ESPEN. 2021;42:292-298. 

Morais J et al Gut Microbes, 2020,  9;12(1):1785804

Mota I et al. 2019, BMJ Open, 9, e028916.

Morais J et al. Neonatology, 2019, 116(2):179-184.

Sá Martins V, Clin Nutr 2019, S0261-5614(19)30311-5. 

Moreira-Rosário A. Eur J Nutr  2019, 19:1-11

Moreira-Rosário A. et al BMJ Open  2019,17;9(1):e023662. 

Faria G et al. Int J Surg. 2015,14:75-9. 

Costa Leite J, et al. Nutrients. 2017 May 5;9(5):458.

Castro-Correia C et al Int J Pediatr. 2017;2017:6424186. 

Castro-Correia C et al. J Clin Med Res. 2017 Dec;9(12):998-1001. 

Moreira-Rosário A et al. BMJ Open. 2016 Nov 10;6(11):e013098. 

Zhu R et al Front Nutr. 2021 Jun 1;8:685648. 

Lu LW et al. J Nutr Sci. 2021 Apr 23;10:e30. 

Zhu R et al.  Diabetes Care. 2021 May 27:dc203092.

Ismael S et al. Nutrients. 2021 Apr 8;13(4):1228. 

Lee KL et al. Obes Res Clin Pract. 2021 Jan-Feb;15(1):42-48. 

Raben A et al. Diabetes Obes Metab. 2021 Feb;23(2):324-337. 

Cuparencu C et al. Eur J Nutr. 2021 Feb;60(1):179-192.

Swindell N et al. Int J Behav Nutr Phys Act. 2020 Mar 4;17(1):29. 

Sayers SR et al. Diabetologia. 2020 Feb;63(2):313-323. 

Sluik D et al. Am J Clin Nutr. 2019 May 1;109(5):1310-1318. 

Huttunen-Lenz M et al. Psychol Res Behav Manag. 2018 Sep 12;11:383-394. 

Christensen P et al. Diabetes Obes Metab. 2018 Dec;20(12):2840-2851. 

Møller G et al. Nutrients. 2018 Jan 9;10(1):54. 

Silvestre MP et al. Prim Care Diabetes. 2017 Dec;11(6):561-569. 

Møller G et al. Nutrients. 2017 Jul 17;9(7):763. 

Fogelholm M et al Nutrients. 2017 Jun 20;9(6):632. 

  • 2020 - Bolsa Nacional Biocodex- Biocodex Microbiota Foundation. MicroSpA & MicroRA: The role of microbiome on biological therapy efficacy in axial Spondyloarthritis and Rheumatoid Arthritis - a new paradigm”
  • 2019 - Teixeira D, Silvestre MP, Marques C, Vasques M, Pestana D, Faria A, Calhau C. MEDBIOME: Efeito da dieta mediterrânea no microbiana de diabéticos tipo 2. Bolsa Emílio Peres, Sociedade Portuguesa de Diabetologia.
  • 2018 - Mota I, Pestana D, Marques C, Teixeira D, Morais J, Faria A, Cortez AP, Quaresma R, Pinto E, Fernandes V, Maia L, Rosário A, Keating E, Leite J, Almeida A, Azevedo L, Lima R, Calhau C. The iogeneration intervention study at Lisbon: iodine status and iodised salt consumption in school-aged children. Best Poster award in XVII Food and Nutrition Congress, International Congress of Food and Nutrition
  • 2018 - Lau E, Marques C, Teixeira D, Pestana D, Faria A, Rosário A, Carvalho D, Calhau C. Estudo aleatório do efeito da cerveja sem álcool no controlo glicémico de diabéticos tipo 2. Bolsa Emílio Peres, Sociedade Portuguesa de Diabetologia
  • 2017 - Bolsa Milupa Sociedade Portuguesa de Neonatologia DN-EL 2017 “Avaliação da influência do tipo de alimentação em bebés prematuros no microbiota”
  • 2017 - Marta P. Silvestre .Awarded first prize for best oral communication: “Weight loss and its maintenance for type 2 diabetes prevention – the PREVIEW study” – XVI Portuguese Congress of Food and Nutrition
  • Dr. Miguel Vasques, The Howard Hughes Medical Institute (HHMI) and Obesity Laboratory, Instituto Gulbenkian de Ciência, Oeiras, Portugal e Serviço de Encrinologia do Hospital Curry Cabral, Centro Hospitalar Universitário Lisboa Central, Portugal;
  • Profs. Fernando Maltez e Prof. Helder Pinheiro, Serviço de Infecciologia do Centro Hospitalar Universitário Lisboa Central, Portugal;
  • Dr. Francisco Goiana da Silva, Centre for Health Policy, Institute of Global Health Innovation, Imperial College London, London, UK;
  • Prof. Jaime Branco e Prof. Fernando Pimentel, Serviço de Reumatologia Hospital Egas Moniz, Portugal;
  • Dra Ana Correia, Unidade da Mama, Hospital São José, Centro Hospitalar Universitário Lisboa Central, Portugal;
  • Dra Marta Duarte, Unidade de Cirurgia Plástica e Reconstrutiva, Hospital São José, Centro Hospitalar Universitário Lisboa Central, Portugal;
  • Doutor Christophe Espírito Santo e Doutora Inês Brandão, Centro Apoio Tecnológico Agro-Alimentar Castelo Branco, CATAA, Portugal;  
  • Professor Sally D Poppit, Dr. Louise Lu and Dr. Amy Liu, Human Nutrition Unit, University of Auckland, New Zealand;
  • Dra. Inês Maria Guerra Mollet, Cell Death and Disease Lab, NMS|FCM, UNL, Portuga;
  • Professor Mikael Fogelholm and Dr. Eli Jalo, Department of Food and Nutrition, University of Helsinki, Finland
  • Professor Anne Salonen, Human Microbiome Research (HUMI), University of Helsinki, Finland
  • Professor Anne Raben, Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark
  • Dr. Catalina Cuparencu, Department of Preventive and Clinical Research, University of Copenhagen, Denmark
  • Dr. Paul W Caton, Diabetes and Nutrition, Kings College, United Kingdom
  • Professor Luís Filipe Azevedo, Faculty of Medicine, University of Porto (FMUP), Principal Investigator and Lead of the Research Group EvidenS&HTA at CINTESIS and Coordinator of the TL 4 - Healthcare Policy, Technology and Digital Transformation, of the Associate Laboratory RISE.
  • Professora Ana Luísa Trigoso Papoila da Silva, NOVA Medical School|Faculdadede Ciências Médicas (NMS|FCM), UNL, Portugal.
  • Professor Jorge Polónia, CINTESIS/FMUP and Hypertension Unit, Hospital Pedro Hispano, Matosinhos, Portugal.
  • Professora Ana Teresa Freitas, INESC-ID and Department, teaching computationalBiology, Instituto Superior Técnico, da Universidade de Lisboa, Portugal.

Principal Investigator

Diana Teixeira

Team

Conceição Calhau
Vice-Dean for Community Extension
Ana Faria
Júlio César Rocha
Cláudia Marques
André Rosário
Diogo Pestana
Marta P Silvestre
Catarina Durão
Invited Assistant Professor
Mónica Sousa
Juliana Morais
PhD student
Inês Barreiros Mota
Shámila Ismael
PhD student
Inês Castela
MSc Student
Catarina Rodrigues
MSc Student