Our group has mainly been dedicated to research cardiovascular effects associated with hypoxia and oxidative stress, particularly arterial hypertension.
We use phenotypic approaches from a drug- and precision medicine-centered perspective: new therapeutic targets, new drugs, variability in drug response (eg. gender differences) and adverse drug reactions.
Phenotypic approaches include cardiometabolic changes and cardiovascular risk parameters, indicators of renal tubular function, indicators of enzymatic activities and redox changes (eg. sulfotransferases, uNaC, thiolome, indoleamine 2,3-dioxygenase) in in vivo animal models (eg. clinical studies (obstructive sleep apnea, hypertension, chronic kidney disease, HIV-infection).
More recently, the team has been particularly interested in the association between cardiovascular risk factors and environmental exposure through the aryl hydrocarbon receptor AhR receptor.
- Xavier Coumol & Robert Barouki INSERM UMR-S 1124, Toxicologie Pharmacologie et Signalisation Cellulaire & France, Université Paris Descartes, Sorbonne Paris Cité- Oleg A. Mayoboroda - Leiden University Medical Centre, Leiden, The Netherlands- Demotes, ECRIN
- Alexandra Antunes & Matilde Marques - Instituto Superior Técnico- Jacinta Serpa - IPO Lisboa- Joana Miranda - FFUL- Rosário Bronze - IBET- Alessandro Fantoni - ISEL- João Vicente - ITQB- Gabriela Almeida - Egas Moniz- Teresa Branco e Karina Soto Hospital Fernando da Fonseca, Amadora- Anabela Raimundo, Hospital da LUZ- Manuel Almeida e Patricia Branco, CHLO-Margarida Aguiar, HBA-Alexandra Mineiro, CHULC- Inês Alves da ANDO/EUPATI
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