Until 2013, we focused on respiratory diseases and the impact of air quality on the health of the population in several contexts.
Since 2014, we study the integrated mechanisms of disease in multidisciplinary contexts:
The MiniVent aims to develop the evolution of the minimalist ventilator concept for intrusive mechanical ventilation, in pressure control mode, to COVID 19 emergency intensive clinical care with a unique architecture but with several alternatives in terms of the possible components to use, depending on its market availability or local production capacityProject Sheet
This project focuses on the epidemiology of chronic cough and the mechanisms of hypersensitivity of cough syndrome and is led by Nuno Neuparth and funded by MSD Portugal. Cough is an essential protective physiological mechanism that prevents food, liquids, dust, and chemicals from reaching the lower airways. The prevalence of chronic cough in Portugal is unknown. Cough is one of the most common respiratory symptoms that frequently leads people to seek medical care and can be a frustrating difficult problem for patients and clinicians. Whilst some patients cough daily over many years, for others the disease has a relapsing and remitting course making a definition based purely on a temporal basis difficult to sustain. The diagnosis of chronic cough should be made on a global clinical assessment, considering the other features of the phenotypes of cough. The main goal of the EPICOUGH.PT project is to study the prevalence of chronic cough in a set of primary care centers in Lisbon, Portugal using the Fujimura Cough Questionnaire. For that, this project will allow the study of the adult population registered in the different health care centers of ACES Lisboa Central, which serves about 244.000 people (30.000 ≥ 65 years old). The ACES database includes about 63.000 e-mails (13% of which ≥ 65 years old).
EPICOUGH.PT is a cross-sectional study, with two different Phases:
This project was developed by a consortium including the NOVA Medical School, the Association Fraunhofer Portugal Research and the NOS iNovation, and funded by Portugal 2020. Chronic respiratory diseases can affect voice and present some voice-related sounds that are disease-characteristic. The study of the acoustic characteristics of patients’ voices allows the early diagnosis of respiratory diseases. It has been shown that COVID-19 infection can lead to severe respiratory disease, in which coughing is the main symptom. Indeed, we believe the analysis of the voice-related sounds could be used to diagnose people for COVID-19. OSCAR aims at developing an algorithm to identify suspect cases of COVID-19 through the analysis of the characteristics of the voice. Thus, the identification and development of tools to screen suspected cases of COVID-19 infection would be extremely relevant and useful, considering the need for rapid testing to contain this global pandemic. The goal of OSCAR is to develop a smart algorithm to screen for COVID-19, using the characteristics of the voice and epidemiological data collected by an online form and simple vocal tests, thus developing a service for the identification of suspected cases of COVID-19 based on NOS voice technology. Plus, we intend to provide a platform for epidemiological studies using voice data and improve algorithms for the investigation of respiratory diseases.
OSCAR is a cross-sectional study with 300 participants, with two phases:
Promotor | Responsible Center: Faculdade de Ciências Médicas | CHRCPartners: NOS INovação, SA/Associação Fraunhofer Portugal Research/Universidade Politécnica de Madrid/Hospitais da Luz e Beatriz Ângelo/Centro Medicina Laboratorial Germano de SousaAuthors: N.Neuparth/P.Martins/A.Rodrigues/R.Sousa/H.Canhão/J.Sousa/P.Paixão/MJ.Chasqueira/MJR.Sousa/A.Carreiro/F.Soares/I.Sousa/J.Ferreira/SJ.Braga
Araújo-Martins J; Brás-Geraldes C; Neuparth N. "The potential role of peak nasal inspiratory flow to evaluate active sinonasal inflammation and disease severity". Scientific Reports 10 1 (2020): 1-9. doi: 10.1038/s41598-020-69693-6
Erny G; Gomes R; Santos M; Santos L.; Neuparth N; Carreiro-Martins P; Gaspar-Marques J; Guerreiro A; Gomes-Alves P. "Mining for Peaks in LC-HRMS Datasets Using Finnee – A Case Study with Exhaled Breath Condensates from Healthy, Asthmatic, and COPD Patients". ACS Omega 5 26 (2020): 16089-16098. doi:10.1021/acsomega.0c01610
Mendes A, Papoila AL, Carreiro-Martins P, Aguiar L, Bonassi S, Caires I, Palmeiro T, Ribeiro ÁS, Neves P, Pereira C, Botelho A, Neuparth N, Teixeira JP (2017) The Influence of Thermal Comfort on the Quality of Life of Nursing Home Residents. J Toxicol Environ Health A. 2017 May 23:1-11. doi: 10.1080/15287394.2017.1286929
Sousa H, Branco P, de Sousa Almeida M, de Araújo Gonçalves P, Gaspar A, Dores H, Mesquita J, Andrade MJ, Neuparth N, Aleixo A, Mendes M, Barata JD (2017) Changes in albumin-to-creatinine ratio at 12-month follow-up in patients undergoing renal denervation. Rev Port Cardiol. 2017 May;36(5):343-351. doi: 10.1016/j.repc.2016.09.019
Marques IJ, Moura MM, Cabrera R, Pinto AE, Simões-Pereira J, Santos C, Menezes FD, Montezuma D, Henrique R, Teixeira MR, Leite V, Cavaco BM (2017) Identification of somatic TERT promoter mutations in familial non-medullary thyroid carcinomas (FNMTC). Clin Endocrinol (Oxf). 2017 May 14. doi: 10.1111/cen.13375
Rodrigues G, de Araújo Gonçalves P, Moscoso Costa F, Campante Teles R, Hélder D, Mariano L, Brito J, Mesquita Gabriel H, Almeida M, Mendes M. (2017) Low previous cardiovascular risk of patients with ST-elevation myocardial infarction. Coron Artery Dis. 2017 Apr 20. doi: 10.1097/MCA.0000000000000502
Bousquet J, Bewick M, Arnavielhe S, Mathieu-Dupas E, Murray R, Bedbrook A, Caimmi DP, VandenPlas O, Hellings PW, Bachert C, Anto JM, Bergmann KC, Bindslev-Jensen C, Bosnic-Anticevitch S, Bouchard J, Canonica GW, Chavannes NH, Cruz AA, Dahl R, Demoly P, De Vries G, Devillier P, Fink-Wagner A, Fokkens WJ, Fonseca J, Guldemond N, Haahtela T, Hellqvist-Dahl B, Just J, Keil T, Klimek L, Kowalski ML, Kuna P, Kvedariene V, Laune D, Larenas-Linnemann D, Mullol J, Pereira AM, Carreiro-Martins P, Melén E, Morais-Almeida M, Nogueira-Silva L, O'Hehir RE, Papadopoulos NG, Passalacqua G, Portejoie F, Price D, Ryan D, Samolinski B, Sheikh A, Simons FE, Spranger O, Bom AT, Tomazic PV, Triggiani M, Valero A, Valovirta E, Valiulis A, van Eerd M, Wickman M, Young I, Zuberbier T (2017) Work productivity in rhinitis using cell phones: The MASK pilot study. Allergy. 2017 Apr 7. doi: 10.1111/all.13177
Schultz MJ, Dunser MW, Dondorp AM, Adhikari NK, Iyer S, Kwizera A, Lubell Y, Papali A, Pisani L, Riviello BD, Angus DC, Azevedo LC, Baker T, Diaz JV, Festic E, Haniffa R, Jawa R, Jacob ST, Kissoon N, Lodha R, Martin-Loeches I, Lundeg G, Misango D, Mer M, Mohanty S, Murthy S, Musa N, Nakibuuka J, Serpa Neto A, Nguyen Thi Hoang M, Nguyen Thien B, Pattnaik R, Phua J, Preller J, Povoa P, Ranjit S, Talmor D, Thevanayagam J, Thwaites CL, Global Intensive Care Working Group of the European Society of Intensive Care Medicine (2017) Current challenges in the management of sepsis in ICUs in resource-poor settings and suggestions for the future. Intensive Care Med. 2017 Mar 27. doi: 10.1007/s00134-017-4750-z
Khan F, Owens MB, Restrepo M, Povoa P, Martin-Loeches I. (2017) Tools for outcome prediction in patients with community acquired pneumonia. Expert Rev Clin Pharmacol. 2017 Feb;10(2):201-211. doi: 10.1080/17512433.2017.1268051
Caroça C, Vicente V, Campelo P, Chasqueira M, Caria H, Silva S, Paixão P, Paço J.(2017) Rubella in Sub-Saharan Africa and sensorineural hearing loss: a case control study. BMC Public Health. 2017 Feb 1;17(1):146. doi: 10.1186/s12889-017-4077-2
Professor Paulo Paixão, clinical researcher at Integrated Pathophysiological Mechanisms, is a guest on the documentary series on RTP1, Vírus - Parasitas Obrigatórios.
Project partners include NOVA Medical School, CHRC, NOS Innovation, Fraunhofer Portugal and Polytechnic University of Madrid
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