Cardiovascular, renal, and metabolic diseases, collectively known as CaRe-Me conditions, stand as the primary global causes of mortality. The escalating prevalence of hypertension, type 2 diabetes, and obesity, significantly drives the surge in CaRe-Me diseases and related comorbidities from foot ulcers to neurodegenerative diseases. Importantly, the increasing rates of dysmetabolism, coupled with an ageing population will dramatically increase the risk of CaRe-Me diseases over the next decade. Many of these conditions remain under-diagnosed and under-treated.
The Cardiovascular, Renal, and Metabolism research area at NMS gathers highly interdisciplinary teams of researchers, from biomedical researchers, clinical researchers and nutritionists, who perform their research either at NMS laboratories or at NMS affiliated or partner hospitals. By combining epidemiological studies, designing, and implementing clinical trials, developing, and employing disease models, access to human-derived samples, identifying both conventional and innovative biomarkers, and capacity to develop devices, the researchers of this area aim to:
- Understand the causative molecular mechanisms and their regulation to pursue prevention and new therapies and identify therapeutic targets for better management of CaRe-Me diseases or its risk factors.
- Find novel biomarkers with clinical utility to establish an early diagnosis and to guide preventive and treatment strategies.
- Develop novel monitoring tools that evaluate health status, and to capacitate the individual to assess the impact of life-style changes.
- Produce scientific evidence to empower patients and vulnerable population groups to promote better health or better disease management.
CaRe-Me is multiconnected with the other NMS research areas and operates in a national and international setting which is essential to drive significant discoveries and enhance healthcare on a global scale.
